Tinnitus, Enophthalmos, And Transient Thrombocytopenia As Symptoms Of Metastatic Breast Cancer Without Local Disease

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Gianni D’Egidio H.BSc, M.D., M.Eng
Kwadwo Kyeremanteng MD MHA

oculopharyngeal muscular dystrophy, tinnitus, thrombocytopenia, enophthalmos,


A 57 year old woman with a past medical history of oculopharyngeal muscular dystrophy presents with tinnitus, thrombocytopenia, and enophthalmos. She then develops subcutaneous skin nodules on her abdomen. Initial biopsies of the cutaneous nodules revealed adenocarcinoma of unknown origin. CT imaging of her chest, abdomen, and pelvis reveal atypical peritoneal carcinomatosis and possible diffuse bone marrow infiltration. CA -125, CEA and CA-19 are negative. Upper and lower endoscopies are normal along with bilateral mammograms of the breast. Repeat biopsy of the skin nodules and bone marrow biopsy reveals lobular carcinoma of the breast. She is treated with hormone modifying therapy for approximately one year but subsequently passes away.
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