Hyponatremia Due to an Interaction Between Hydromorphone and Desmopressin in a Patient with Central Diabetes Insipidus: A Case Report

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Gillian Mazzetti MD
Oren Steen MD
Ameen Patel MD
Natalia McInnes MD

Hydromorphone, hyponatremia, desmopressin, central diabetes insipidus


There are case reports of opiate-induced hyponatremia thought to be mediated by increased secretion of antidiuretic hormone. We report a case of hyponatremia in a woman with central diabetes insipidus treated with desmopressin after receiving large doses of hydromorphone which suggests a different mechanism of opiate action.
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