Acute Hepatitis B Co-infection in HIV-Infected Patients Despite Prior Hepatitis B Vaccination

Main Article Content

S. Rolland
L. Antonova
J. Powis
T. Murdoch
D. Wong
P. James MD, MSc, FRCPC

Abstract

Clinicians often assume that patients vaccinated for hepatitis B virus (HBV) have immunity. We report three cases of acute HBV infection in HBV-vaccinated HIV patients. These cases illustrate that patients at an elevated risk of HBV exposure presenting with acute hepatitis should be tested for HBV infection regardless of previous vaccination status.
Abstract 435 | PDF Downloads 366

References

1. Lee WM. Hepatitis B virus infection. N Engl J Med 1997;337:1733–45.
2. Homann C, Krogsgaard K, Torp-Pedersen C, et al. High incidence of hepatitis B infection and evolution of chronic hepatitis B infection in patients with advanced HIV infection. J AIDS 1991;4:416–20.
3. Floreani A, Baldo V, Cristofoletti M, et al. Long-term persistence of anti-HBs after vaccination against HBV: an 18 year experience in health care workers. Vaccine 2004;22(5–6):607–10.
4. Rey D, Krantz V, Partisani M, Schmitt M, et al. Increasing the number of hepatitis B vaccine injections augments anti-HBs response rate in HIV-infected patients. Effects on HIV-1 viral load. Vaccine 2000;18:1161–65.
5. Brook G. Prevention of viral hepatitis in HIV co-infection. J Hepatol 2006;44:S104–S107.
6. Wainwright R., Bulkow L, Parkinson A, Zanis C, McMahon B. Protection provided by hepatitis B vaccine in a Yupik Eskimo population – results of a 10-year study. J Inf Diseases 1997;175:674–7.
7. Hollinger B. Factors influencing the immune response to hepatitis B vaccine, booster dose guidelines, and vaccine protocol recommendations. Am J Med 1989;87(suppl 3A):36S–40S.
8. Lin HS, Chang Liao H-W, Lin S-K, Wang L-Y. HLA and response to booster hepatitis B vaccination in anti-HBs-seronegative adolescents who had received primary infantile vaccination. Vaccine 2008;26:3414–20
9. Li Y, Ni R, Song W, Shao W, et al. Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth. Hum Genet, 2009;126:685–96.
10. Tacke F, Amini-Bavil-Olyaee S, Heim A, et al. Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient. J Clin Virol 2007;38:353–7.
11. Francis D, Hadler S, Thompson S, et al. The prevention of hepatitis B with vaccine. Report of the Centers for Disease Control multi-center efficacy trial among homosexual men. Annals Int Med 1982;97:362–66.
12. McMahon BJ, Bruden DL, Petersen KM, et al. Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-up. Ann Intern Med 2005;142(5):333–41.