The Recurrent Flush: A Case and Review of Systemic Mastocytosis

Main Article Content

Wasim Mansoor
Rodrigo Cavalcanti
Shaan Chugh

Keywords

Systemic Mastocytosis, Histamine, Mast Cells, Myeloproliferative Disorder, Anaphylaxis

Abstract

Systemic Mastocytosis (SM) is a hematologic neoplasm characterized by an abnormal proliferation of mast cells, which have the potential to infiltrate one or more visceral organs.  Patients can present with a wide constellation of symptoms making it a challenging diagnosis for clinicians.  Non-specific symptoms such as fatigue, headache, and weight loss may predominate; however, some patients may present with acute onset of urticaria, flushing, and diarrhea. Due to its rarity, clinicians often face a challenge in evaluating, diagnosing and effectively treating systemic mastocytosis.  Identification during the indolent phase is important as SM can progress to aggressive leukemias or myeloproliferative disorders. In this article, we present a case of SM, and discuss current practices in diagnosis, evaluation and management.  We conclude with future directions for treatments and diagnosis
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