A Challenging Case of Non-resolving Pneumonia: Keeping Antisynthetase Syndrome In the Differential Diagnosis

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Stephanie Lapinsky, MD
Jessica Leen, MD
Jessica Mak, BSc. Pharm (Hons), RPh. MD Candidate 
Mohammed A. Shafiee, MD


A 62-year-old Caucasian female ex-smoker presented to the emergency department with progressive shortness of breath with associated pleuritic chest pain, new arthralgias, and muscle weakness for two months. She had already been treated with two courses of antibiotics for suspected community acquired pneumonia (CAP) with no improvement in her respiratory symptoms. This is a case that illustrates the eventual diagnosis of antisynthetase syndrome, a subtype of the idiopathic inflammatory myopathies. Current standard of diagnostic criteria and treatment for this autoimmune condition will also be discussed. 

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