Physicians’ Appraisal and Response to Early Evidence on Cardiovascular Risk Associated with Rosiglitazone: Knowledge Translation in Clinical Practice

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Garielle E. Brown
Adriane M. Lewin MSc
Michael A. De Souza BSc
Alun L Edwards MD
William A. Ghali MD MPH
Doreen M. Rabi MD MSc


safety of rosiglitazone, hypoglycemic agent, treatment of type 2 diabetes mellitus,


In 2007, a high-profile meta-analysis raised concerns about the safety of rosiglitazone, a thenpopular oral hypoglycemic agent. In this study, the authors describe how physicians accessed, evaluated, and applied this information clinically. Their findings showed that although a highly publicized meta-analysis raised concerns among physicians, meta-analyses can be challenging to interpret. Efforts are needed to improve the understanding of this methodology to aid physicians in translating results into practice.
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