Severe Acute Cytomegalovirus Infection Complicated by Disseminated Intravascular Coagulation and Pneumonitis in a Healthy Female

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Zain Chagla MD
Deborah Siegal MD
Phillippe El-Helou MD
Wendy Lim MD
Jill Rudkowski MD


Cytomegalovirus (CMV) is an endemic infection worldwide. Among healthy individuals, infections are usually asymptomatic. An infectious mononucleosis-type syndrome is classically described. More serious manifestations, such as pneumonitis, hepatitis, and meningoencephalitis have been described in otherwise healthy populations. Disseminated intravascular coagulation is a life-threatening complication that is extremely rare in competent hosts. We describe a case of pneumonitis and DIC associated with acute CMV infection that resolved with antiviral therapy.
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